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Systemic lupus erythematosus and antiphospholipid syndrome
Major attack internal organs (kidney, parkinsons lung, cardiac, neuropsychiatric, hematologic) can prove fatal. Some patients have concomitant antiphospholipid syndrome, which is characterized clinically by thrombosis (arterial or venous), abortion, and thrombocytopenia, and the laboratory by the presence of anticardiolipin antibodies and / or lupus anticoagulant. Pregnancy parkinsons can adversely affect the course of the wolf and vice versa. Epidemiology Women are affected more often (ratio parkinsons women: men 9: about 1) in fertile age. Lupus is more common in Asians or people with ancestry from Africa or the Caribbean than in whites. Reason Unknown. Certain drugs (e.g. hydralazine) can induce systemic lupus erythematosus. Clinical parkinsons features The wolf can cause almost any kind of clinical feature. Some common parkinsons findings are fatigue, fever, photosensitivity (rash sidewalls parkinsons - Fig 33), mouth sores, alopecia, this phenomenon Raynaud, the syndrome secondary to Sjögren (dry eyes and dry mouth) and arthralgia / arthritis. It should always be discussed the possibility of infection in patients with lupus and poor general condition (Fig. 34). Lupus patients at increased risk for atherosclerosis. Fig 33 Rash cheeks (type "butterfly") in systemic lupus erythematosus.
Fig 34 monoarthritis left ankle in a patient with systemic lupus erythematosus, septic probably parkinsons nature. Patients with lupus are at increased risk of sepsis. The ankle was edematous and erythematous, parkinsons warm and sensitive on palpation. The movement was very painful.
Investigations Regular testing of urine through Dipstix (for blood levels and protein) can quickly demonstrate the presence of renal disease. It may manifest anemia (hemolytic probably), leukopenia or thrombocytopenia. Over 95% of patients are positive for antinuclear antibodies. The antibodies against double-stranded DNA have high specificity for SLE and are a useful measure of disease activity. Treating Patients should use strong sunscreen whenever needed. Blood pressure should be monitored and controlled carefully. Many patients benefit from antimalarial drugs. Steroids and immunosuppressive therapy is indicated in serious cases of active disease. Counseling before pregnancy is particularly important in young women. Clinical course varies and depends on the degree of infestation of internal organs. e-alexandria.eu parkinsons
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