Nowadays, there is serological conflict as often as before. However, due to the development of conflict prevention its negative effects on the fetus already appear very rarely. It's fair to say that the consequences of the conflict serological dealing only in those cases in which the obstetrician sees a woman for the first time on the day of birth.
The conflict serological say in a situation in which the body produces antibodies acute myeloid leukemia to fight maternal fetal blood cells. This is due to the presence of the so-called. antigens on fetal blood cells, acute myeloid leukemia absent from the maternal blood cells. Mother as a result of immunization (contact with a foreign antigen) antibody production begins. This applies both to the Rh factor (the most popular) or any other blood group system (ABO, Kell, Duffny etc.).
The hemolytic disease we say in a situation where there is a contact of antibodies produced as a result of the conflict in maternal acute myeloid leukemia blood of fetal blood cells. The disease affects only the fetus and the mother is asymptomatic.
There are three clinical forms of hemolytic disease of the newborn: Generalized edema of the fetus - it is the hardest form, characterized by swelling acute myeloid leukemia of the skin and subcutaneous tissue, which may be accompanied by petechiae. This form is subject acute myeloid leukemia to a high rate of intrauterine obumarć. It is found very rarely now - thanks to effective prevention. Severe hemolytic jaundice - in the newborn in the first days of life after birth, symptoms of jaundice. If it is not taken immediate treatment, may be exceeded the limit of bilirubin in the blood and as a result - the child's brain damage. Again, this form of the disease is extremely rare. Severe degree of anemia (anemia) - This form occurs more frequently than those mentioned acute myeloid leukemia above, but it is a milder version acute myeloid leukemia of the disease. Symptoms are characteristic of anemia. The child is pale, has enlarged liver and spleen. May exhibit characteristics of dyspnea (movements nostrils during breathing, wheezing, retraction intercostal acute myeloid leukemia space).
The disease is generally not observed during the first pregnancy. However, in the first child during childbirth a transition w / w of antigens from the fetal blood into the mother's blood and antibody production occurs. At the next pregnancy antibodies are already present in maternal blood (IgG), so can pass through the placenta acute myeloid leukemia and damage the cells of the fetus. Number of hemolytic disease depends primarily on the amount of immunoglobulin produced by the mother and from the stage of pregnancy, in which a transition antibodies. The earlier the fetal cells are damaged, the worse the prognosis. In contrast, cases of hemolytic disease starting in late pregnancy are generally far milder course.
Women during pregnancy remain under medical supervision, making the standard procedures and regular gynecological examinations should not be afraid of the negative consequences of the conflict serological fetus. The frequency with which it comes into the presence of non-compliance, it is currently estimated at about 20% - 24%. In every tenth pregnancy incompatibility comes to the development acute myeloid leukemia of the conflict. This represents approximately 2% of all pregnancy.
These women, who have not made the sign of blood group, acute myeloid leukemia Rh factor, or antibody levels before pregnancy, should have done this kind of diagnosis in the first trimester of pregnancy. In women with Rh-negative blood group antibody level test is repeated at 28 weeks of pregnancy. This study aims to determine whether during pregnancy, there was no seroconversion, ie the production of antibodies by the mother's acute myeloid leukemia body. Women diagnosed with the presence of antibodies against the fetal blood cells should be repeated at intervals of four studies (28, 32, 36) to assess the titer (level) antibodies. In addition, it is suggested to carry out regular ultrasound for possibly emerging fetal hemolytic disease symptoms. acute myeloid leukemia This gives the possibility of an early statement of changes and to take effective action. In order to recognize the disease in some women inspections performed under ultrasound umbilical vein puncture and blood download acute myeloid leukemia it for testing. acute myeloid leukemia Subsequently, the material evaluated for the presence of Rh and maternal antibodies destroy fetal cells.
In the treatment of serological conflict strive to remove acute myeloid leukemia excess bilirubin (created in the process acute myeloid leukemia of destruction of red blood cells); removal of circulating antibodies from the blood of the fetus (those that arose in maternal blood and crossed the placenta); alignment blood morphological parameters (hemoglobin, red blood cells); insensitive to the administration Matcze
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