What is the etiology keep calm of vitiligo | nandoweb.com
The disease causes the outstanding clear. Recent studies have considered the following factors: keep calm 1. Genetic study says some studies show that Vitiligo keep calm may be an autosomal keep calm dominant skin disease. Abroad statistics 30% of patients have a positive family keep calm history, found in two monozygotic twins are sick. domestic keep calm reported a positive family history of 3% to 12% lower than the foreign reports. 2. Autoimmune Pok Pok said autoimmune pathogenesis of vitiligo say with increasing attention Many Pok patients and their family members noticed merged higher rates of autoimmune disease, a common thyroiditis, hyperthyroidism or hypothyroidism, diabetes, chronic adrenal hypofunction, keep calm pernicious anemia, rheumatoid arthritis, pernicious melanoma, while the serum of patients with vitiligo, was detected in a variety of organ-specific antibodies, such as anti-thyroid antibodies, anti-gastric parietal cell antibodies, anti-adrenal antibody, anti-parathyroid antibody, anti-smooth muscle antibody and detection rate is significantly higher. Further autoimmune disease, keep calm vitiligo incidence than the general population is 10 to 15 times of vitiligo patients have recently been found to have anti-melanocyte cell surface antigens, known as vitiligo antibody titer and the patient's keep calm skin depigmentation degree, titers increased with the expansion of the lesion area, also found that animals suffering from vitiligo have a similar phenomenon, a disease is melanocyte autoimmune disease. Behl (1977) found that during the period of white edges monocyte aggregates, invade keep calm the dermal-epidermal junction, by the destruction of the basement membrane into the epidermis, so that it melanocytes and melanin agenesis, that the disease may be delayed keep calm hypersensitivity autoimmune disease. Additionally, Oral or topical corticosteroids, especially not by the distribution of skin lesions better effect sections, but also indirectly proved immune mechanism of the disease. 3. mental and neurological Pok Pok Pok said many clinical findings mental factors and the incidence of vitiligo closely related, it is estimated that about 2/3 of patients with lesions keep calm in the onset or development stage of trauma, stress, depression or depressed. tension can be caused by increased catecholamines, such as adrenaline can directly affect the bleaching; Stress can also be the ACTH secretion increased, resulting in increased secretion of corticosteroids, and the mobilization of sugar and free fatty acids stimulate insulin secretion, insulin indirectly stimulate the brain to increase L-tryptophan, which the brain 5 - HT synthesis, keep calm while the 5 - serotonin metabolism product is melatonin, pheomelanin receptor hyperactivity in the pathogenesis of vitiligo play an important role. melatonin receptor hyperactivity increase theophylline enzyme activity keep calm of these enzymes inhibited melanin biochemistry, but later they make students generation of activation, resulting in melanin metabolism of toxic intermediates accumulate in melanocytes, the melanocytes die eventually lead vitiligo have white spot at Pok observed degenerative nerve endings there, but the degree of change seems related to disease keep calm progression This phenomenon also supports the nerves of Pok Pok said. 4. melanocytes destroy themselves (self-destruction of melanocytes) Pok said basic lesion of vitiligo epidermal melanocytes partial or complete keep calm loss of function. Lerner1971 Pok said this was proposed . consider Vitiligo is because hyperactivity epidermal melanocytes, promoting the consumption and the early recession, and may be due to the toxicity of the cells themselves synthesize melanin predecessor due to the accumulation of substances experiments prove certain substances on the curb there melanocytes selective destructive effects, skin bleaching, many of these substances are substituted phenolic keep calm substances Pok bleaching agents such as hydroquinone monomethyl keep calm ether, hydroquinone, Syria butyl phenol, hydrogen peroxide, etc., all of the skin and hair with bleaching effect. keep calm Vitiligo disease has increased in recent keep calm years, may be associated with industrial development, keep calm access to such opportunities Pok substances increased. 5. micronutrient deficiencies Pok said it was suggested that the copper content is reduced in vivo and the pathogenesis of vitiligo, but the determination of serum and hair copper content seems to be no significant difference in the general population, the relevant trace elements Pok said further study. 6 Other factors include trauma, trauma, surgery, scratching, etc. can induce vitiligo. certain endocrine diseases such as hyperthyroidism, diabetes, may be associated with vitiligo. solarization prone vitiligo.
Archives September 2013 May 2013 April 2013 March 2013 February 2013 August keep calm 2012 July 2012 June 2012 May 2012 April 2012 March 2012 February 2012 January 2012 December 2011 November 2011 October 2011 September 2011 August keep calm 2011 July 2011
The disease causes the outstanding clear. Recent studies have considered the following factors: keep calm 1. Genetic study says some studies show that Vitiligo keep calm may be an autosomal keep calm dominant skin disease. Abroad statistics 30% of patients have a positive family keep calm history, found in two monozygotic twins are sick. domestic keep calm reported a positive family history of 3% to 12% lower than the foreign reports. 2. Autoimmune Pok Pok said autoimmune pathogenesis of vitiligo say with increasing attention Many Pok patients and their family members noticed merged higher rates of autoimmune disease, a common thyroiditis, hyperthyroidism or hypothyroidism, diabetes, chronic adrenal hypofunction, keep calm pernicious anemia, rheumatoid arthritis, pernicious melanoma, while the serum of patients with vitiligo, was detected in a variety of organ-specific antibodies, such as anti-thyroid antibodies, anti-gastric parietal cell antibodies, anti-adrenal antibody, anti-parathyroid antibody, anti-smooth muscle antibody and detection rate is significantly higher. Further autoimmune disease, keep calm vitiligo incidence than the general population is 10 to 15 times of vitiligo patients have recently been found to have anti-melanocyte cell surface antigens, known as vitiligo antibody titer and the patient's keep calm skin depigmentation degree, titers increased with the expansion of the lesion area, also found that animals suffering from vitiligo have a similar phenomenon, a disease is melanocyte autoimmune disease. Behl (1977) found that during the period of white edges monocyte aggregates, invade keep calm the dermal-epidermal junction, by the destruction of the basement membrane into the epidermis, so that it melanocytes and melanin agenesis, that the disease may be delayed keep calm hypersensitivity autoimmune disease. Additionally, Oral or topical corticosteroids, especially not by the distribution of skin lesions better effect sections, but also indirectly proved immune mechanism of the disease. 3. mental and neurological Pok Pok Pok said many clinical findings mental factors and the incidence of vitiligo closely related, it is estimated that about 2/3 of patients with lesions keep calm in the onset or development stage of trauma, stress, depression or depressed. tension can be caused by increased catecholamines, such as adrenaline can directly affect the bleaching; Stress can also be the ACTH secretion increased, resulting in increased secretion of corticosteroids, and the mobilization of sugar and free fatty acids stimulate insulin secretion, insulin indirectly stimulate the brain to increase L-tryptophan, which the brain 5 - HT synthesis, keep calm while the 5 - serotonin metabolism product is melatonin, pheomelanin receptor hyperactivity in the pathogenesis of vitiligo play an important role. melatonin receptor hyperactivity increase theophylline enzyme activity keep calm of these enzymes inhibited melanin biochemistry, but later they make students generation of activation, resulting in melanin metabolism of toxic intermediates accumulate in melanocytes, the melanocytes die eventually lead vitiligo have white spot at Pok observed degenerative nerve endings there, but the degree of change seems related to disease keep calm progression This phenomenon also supports the nerves of Pok Pok said. 4. melanocytes destroy themselves (self-destruction of melanocytes) Pok said basic lesion of vitiligo epidermal melanocytes partial or complete keep calm loss of function. Lerner1971 Pok said this was proposed . consider Vitiligo is because hyperactivity epidermal melanocytes, promoting the consumption and the early recession, and may be due to the toxicity of the cells themselves synthesize melanin predecessor due to the accumulation of substances experiments prove certain substances on the curb there melanocytes selective destructive effects, skin bleaching, many of these substances are substituted phenolic keep calm substances Pok bleaching agents such as hydroquinone monomethyl keep calm ether, hydroquinone, Syria butyl phenol, hydrogen peroxide, etc., all of the skin and hair with bleaching effect. keep calm Vitiligo disease has increased in recent keep calm years, may be associated with industrial development, keep calm access to such opportunities Pok substances increased. 5. micronutrient deficiencies Pok said it was suggested that the copper content is reduced in vivo and the pathogenesis of vitiligo, but the determination of serum and hair copper content seems to be no significant difference in the general population, the relevant trace elements Pok said further study. 6 Other factors include trauma, trauma, surgery, scratching, etc. can induce vitiligo. certain endocrine diseases such as hyperthyroidism, diabetes, may be associated with vitiligo. solarization prone vitiligo.
Archives September 2013 May 2013 April 2013 March 2013 February 2013 August keep calm 2012 July 2012 June 2012 May 2012 April 2012 March 2012 February 2012 January 2012 December 2011 November 2011 October 2011 September 2011 August keep calm 2011 July 2011
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