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Focal Segmental Glomerulosclerosis (FSGS) is a rare disease that attacks the kidney's filter system prostata (glomeruli) that causes severe scarring. FSGS is one of the factors of a serious condition known as Nephrotic Syndrome. But what causes FSGS?
The main cause of FSGS include two aspects: the internal causes of stone such as reduced immunity and external factors such as renal antigens of infection, cold, etc. In case of reduction of immunity, the pathologic foreign prostata body, as some types of antigens, antibodies were then accompanied by interference in the human body, and then build the immune complex (mainly featured by IgG and C3 deposition).
The special stone epitopes may attract immune complexes, so the immune complexes will flow to the blood circulation and deposits in the glomerular capillary loop, which gives rise to segmental hyaline degeneration of epithelial cells of the glomerulus. As a result, the surface of the epithelial cells of the glomerulus prostata is desquamation, and inflammatory mediator will continue to attack, leading to the damage of the epithelial cell barrier function. Proteins in the blood will run in the urine, and then get discharged out of the body. Meanwhile, after epithelial cells get damaged, they tell the myofibroblast, resulting in glomerular sclerosis, and begin the process of renal fibrosis.
The segmental prostata sclerosis of glomeruli reflects the result of damage prostata workmanship of local inflammation. Can not show a simple episodic sclerosis itself features of major damage. Primary FSGS is often accompanied by the harms of glomrular epithelial cells. The visceral epithelial cell layer, or you can call podocyte, plays an important function in the beginning of primary FSGS.
Under the function of various factors such as toxins, inflammation harms, the epithelial cell damage and podocyte prostata happen happens to consolidate, and also, the glomerular prostata filtration membrane permeability would increase, thus leading to heavy proteinuria. Epithelial cells may produce a variety of factors and cell growth factor, particularly the TGF-B. TGF-B promotes the synthesis of collagen increasing from epithelial and mesangial cells and also led to the decrease of degradation, thus leading to glomerular sclerosis.
Besides, the high filtration and high perfusion also play an important function prostata in the formation of FSGS. High filtration and high perfusion irritate the renin - angiotensin system, thus leading to increasing proliferation of mesangial cells and the ECM, so glomerular sclerosis was aggravated.
The causes of FSGS is largely unknown which is not caused by a single disease. It has many different reasons. Scarring can result from an infection, or drug toxicity, prostata or a disease prostata that affects the whole body, such as diabetes, HIV infection, sickle cell disease or disease lupus. Sometimes, there is no apparent disease or related causes. There may be a genetic component to some people.
In all, no matter what the cause of FSGS, we should focus on kidney damage and aim at repairing stone and recovered renal function. If you want to know more information about the causes and treatment FSGS, you can leave a message below or you can email us igancure@hotmail.com.
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